KMID : 0978920040050040474
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Korean Journal of Clinical Geriatrics 2004 Volume.5 No. 4 p.474 ~ p.483
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The Relationship between C-reactive Protein and Brachial-ankle Pulse Wave Velocity in Hypertention Patients
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Lee Ji-Won
Kim Sang-Hwan Lim Ji-Ae Lee Duk-Chul
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Abstract
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Background: C-reactive protein (CRP) levels predict outcome in hypertensive patients with atherosclerosis. Arterial stiffness also independently predicts all-cause and cardiovascular mortality and may be involved in process of atherosclerosis. The aim of this study was to investigate the relationship between brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and inflammation.
Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were assessed in 63 individuals. Age, gender, smoking, pulse pressure, body mass index (BMI) ,fasting blood glucose, lipid parameters, CRP, lipoprotein (a) were measured. Pearson¡¯s correlation analysis and multiple regression analysis were conducted to identify the relationship betweeen baPWV and parameters.
Results: Brachial-ankle pulse wave velocity (baPWV) was correlated significantly with age (r=0.497; P£¼0.001), pulse pressure (r=0.454; P=0.001), high density lipoprotein (r=0.286; P=0.023), and CRP (r=0.288; P=0.022). In multiple regression models, after adjustment for age, gender, BMI, heart rate, pulse pressure, high density lipoprotein, and hypertension medication, baPWV was independently correlated with CRP (adjusted R2=0.417, P=0.034).
Conclusion: Brachial-ankle pulse wave velocity had a significant relation with levels of CRP in patients with hypertension, suggesting that inflammation may be involved in arterial stiffening.
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KEYWORD
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Brachial-ankle pulse wave velocity, C-reactive protein, Inflammation
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